A data set of extensive wild-population samples. The population was used together with comparative genome sequence data to illuminate the scope and patterning of wild cotton diversity across its native range. Analyses confirm the hypothesis that the Yucatán Peninsula (México) is the center of domestication, from which the original perennial forms and later modern annualized cultivars were derived. (Ning W, et al. Genomic diversity and the domestication history of cotton (Gossypium hirsutum). PNAS 2026)